If you look at the framework subreddit and their forums you can see different setups people are using successfully. I think the only caveats are that Linux does

If you look at the framework subreddit and their forums you can see different setups people are using successfully. I think the only caveats are that Linux doesn't reliably support hotswapping in some configurations (Windows is fine), and if you get a super-beefy GPU you'll still be bottlenecked by other things