My point is that using non-native tooling might conflict with the native tooling which presumably still exists and is managing some non-trivial portion of the s

My point is that using non-native tooling might conflict with the native tooling which presumably still exists and is managing some non-trivial portion of the system (at the very least, the base installation, but probably a bunch of other packages as well), so whether or not that conflicts with an external package manager is likely to vary by distro.