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Defintion: The Glycemic Index (GI) is a measure of the extent of the change in blood glucose content (glycemic response) following consumption of digestible car

Defintion: The Glycemic Index (GI) is a measure of the extent of the change in blood glucose content (glycemic response) following consumption of digestible carbohydrate, relative to a standard such as glucose. Blood glucose is actively regulated by your body via relying on glycogen storage and breakdown in the muscles and liver, in healthy humans this system reacts quickly to maintain a constant blood glucose level (required for say, active brain function). See figure 1 in this review (pdf) of glycogen-related inherited diseases for an overview of how it's supposed to work (it's all tied into the cellular Krebs, aka tricarboxylic acid, cycle): https://www.researchgate.net/profile/Joseph-Wolfsdorf/publication/10871497_Glycogen_Storage_Diseases/links/02e7e518d6d509a87f000000/Glycogen-Storage-Diseases.pdf https://www.researchgate.net/profile/Joseph-Wolfsdorf/public... Practically speaking, flooding your bloodstream with sugar (soft drinks, candy) seems to overwhelm the normal functioning of that system, but when you eat more complex carbohydrates which are slowly digested (potatoes, bread, pasta, etc.) this results in a steady but slow input of sugars to the bloodstream via the digestive system, which, depending on your resting energy level, will be either stored as glycogen or fed into the Krebs cycle for cellular energy conversion.

renewiltord 4y ago
So if glycemic response means > change in blood glucose content (glycemic response) then does that mean an impaired response is higher or does it mean it's lower?
- brnaftr361 4y ago
  If you don't know, insulin signals a process for sequestering sugars through glycogenesis. Stevia and Glucose groups both increased plasma insulin. Contrasted with Saccharine and Sucralose which, the authors suggest, blunted insulin release and thus increased blood sugar. They cite a paper indicating that combined NNS and caloric sweeteners increase the insulin response compared with a NNS itself. So... both..? It's a disproportion. NNS should have negligible impact on blood sugar to be called "inert", either when paired or when not, regardless of whether glucose is present or not. Addition is changing the whole formula. They're saying it's fucking up the signal interpretation. At least that's what I've put together.
  - renewiltord 4y ago
    Thank you. So let me see if I get it correct. thing effect on plasma insulin gut result glucose baseline increase standard g+sucralose increase less than baseline altered g+stevia baseline increase altered g+aspartame baseline increase altered So since there was lower than baseline increase in the g+sucralose group, we can conclude that the sucralose is blunting the response that the glucose would have caused. So, in this context, that means we got increased blood sugar because of the lower plasma insulin? Okay. I think I understand now.
baby-yoda 4y ago
one point of contention - potatoes and bread (specifically white) are some of the highest GI foods available. i specifically use these (white bread with peeled boiled potatoes) for their quick conversion to available sugars prior to exercise. some scales actually use white bread as the index point (GI = 100) because of this.
- Max-q 4y ago
  Potatoes have gotten an undeserved bad reputation. Boiled potatoes can be as 58. Especially if you cool and reheat. Mashed or fried is over 100.
deleted 4y ago
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renewiltord 4y ago

So if glycemic response means > change in blood glucose content (glycemic response) then does that mean an impaired response is higher or does it mean it's lower?

brnaftr361 4y ago
If you don't know, insulin signals a process for sequestering sugars through glycogenesis. Stevia and Glucose groups both increased plasma insulin. Contrasted with Saccharine and Sucralose which, the authors suggest, blunted insulin release and thus increased blood sugar. They cite a paper indicating that combined NNS and caloric sweeteners increase the insulin response compared with a NNS itself. So... both..? It's a disproportion. NNS should have negligible impact on blood sugar to be called "inert", either when paired or when not, regardless of whether glucose is present or not. Addition is changing the whole formula. They're saying it's fucking up the signal interpretation. At least that's what I've put together.
- renewiltord 4y ago
  Thank you. So let me see if I get it correct. thing effect on plasma insulin gut result glucose baseline increase standard g+sucralose increase less than baseline altered g+stevia baseline increase altered g+aspartame baseline increase altered So since there was lower than baseline increase in the g+sucralose group, we can conclude that the sucralose is blunting the response that the glucose would have caused. So, in this context, that means we got increased blood sugar because of the lower plasma insulin? Okay. I think I understand now.

baby-yoda 4y ago

one point of contention - potatoes and bread (specifically white) are some of the highest GI foods available. i specifically use these (white bread with peeled boiled potatoes) for their quick conversion to available sugars prior to exercise. some scales actually use white bread as the index point (GI = 100) because of this.

Max-q 4y ago
Potatoes have gotten an undeserved bad reputation. Boiled potatoes can be as 58. Especially if you cool and reheat. Mashed or fried is over 100.

deleted 4y ago

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