5 ms·

Green tea and resveratrol reduce Alzheimer's plaques in lab tests

21 points by birriel 4y ago

jleyank 4y ago
Problem is, the biological model of Alzheimer’s isn’t panning out. They have drugs that reduce plaques but they don’t improve peoples conditions. Seems they need new models to try again. Billions have been thrown in this hole, but it’s such a huge market they’ll keep doing it if anything shows promise.
- melling 4y ago
  …or would could build better tools that enable us to monitor and examine the human body.
- midislack 4y ago
  It's not panning out because of fraud. 20+ years of research down the drain.
gumby 4y ago
It's not even clear if the plaque is a cause, side effect, or even the body's attempt at fighting back. This was discussed a few months ago on HN: https://news.ycombinator.com/item?id=32183302 https://news.ycombinator.com/item?id=32183302
refurb 4y ago
GSK paid $720M for a resveratrol company back in 2008 and recently dumped all development due to weak efficacy and renal toxicity risks. I'll pass. https://www.fiercebiotech.com/biotech/weak-efficacy-renal-risks-force-gsk-to-dump-a-resveratrol-program https://www.fiercebiotech.com/biotech/weak-efficacy-renal-ri...
- rongopo 4y ago
  Please could you provide a source?
  - chewz 4y ago
    https://www.youtube.com/watch?v=vpxQoGk_ryg https://www.youtube.com/watch?v=vpxQoGk_ryg and more on his channel
    - rongopo 4y ago
      No. A youtube channel is not a legitimate source. It is a channel. For a source see https://www.nature.com/articles/s41598-017-03635-7 https://www.nature.com/articles/s41598-017-03635-7
      - hulitu 4y ago
        For me, the difference between youtube and nature.com is quiet low. Nature.com declares a "breaktrough" every other day.
        rongopo 4y ago
        Just an example, the wise way is to read scientific research and reviews showing both sides and form a grounded opinion.
        chewz 4y ago
        The fact is that the owner of this particular chanel is MD and the channel format is host talking while citations from relevant scientific research papers are highlighted on screen. Better then Nature..
k_sze 4y ago
Trying to find occurrences of “mouse”/“mice” in Alzheimer’s articles as soon as they show up on HN frontpage is now a meme of mine. PS: there is none this time, which is progress, I guess?
- tsol 4y ago
  They're lab tests, which means they are just testing in a petri dish. These ones are easy to use human cells with-- but they tell you very little about the effect of a human taking it at a reasonable dose

21 points by birriel 4y ago

Problem is, the biological model of Alzheimer’s isn’t panning out. They have drugs that reduce plaques but they don’t improve peoples conditions. Seems they need new models to try again. Billions have been thrown in this hole, but it’s such a huge market they’ll keep doing it if anything shows promise.

melling 4y ago
…or would could build better tools that enable us to monitor and examine the human body.
midislack 4y ago
It's not panning out because of fraud. 20+ years of research down the drain.

gumby 4y ago

It's not even clear if the plaque is a cause, side effect, or even the body's attempt at fighting back. This was discussed a few months ago on HN: https://news.ycombinator.com/item?id=32183302 https://news.ycombinator.com/item?id=32183302

refurb 4y ago

GSK paid $720M for a resveratrol company back in 2008 and recently dumped all development due to weak efficacy and renal toxicity risks. I'll pass. https://www.fiercebiotech.com/biotech/weak-efficacy-renal-risks-force-gsk-to-dump-a-resveratrol-program https://www.fiercebiotech.com/biotech/weak-efficacy-renal-ri...

rongopo 4y ago
Please could you provide a source?
- chewz 4y ago
  https://www.youtube.com/watch?v=vpxQoGk_ryg https://www.youtube.com/watch?v=vpxQoGk_ryg and more on his channel
  - rongopo 4y ago
    No. A youtube channel is not a legitimate source. It is a channel. For a source see https://www.nature.com/articles/s41598-017-03635-7 https://www.nature.com/articles/s41598-017-03635-7
    - hulitu 4y ago
      For me, the difference between youtube and nature.com is quiet low. Nature.com declares a "breaktrough" every other day.
      - rongopo 4y ago
        Just an example, the wise way is to read scientific research and reviews showing both sides and form a grounded opinion.
        chewz 4y ago
        The fact is that the owner of this particular chanel is MD and the channel format is host talking while citations from relevant scientific research papers are highlighted on screen. Better then Nature..

k_sze 4y ago

Trying to find occurrences of “mouse”/“mice” in Alzheimer’s articles as soon as they show up on HN frontpage is now a meme of mine. PS: there is none this time, which is progress, I guess?

tsol 4y ago
They're lab tests, which means they are just testing in a petri dish. These ones are easy to use human cells with-- but they tell you very little about the effect of a human taking it at a reasonable dose