You don't, but that only really applies to this: >It seems unlikely that it will ever completely solve the problem, and therefore, an entirely different approa

You don't, but that only really applies to this: >It seems unlikely that it will ever completely solve the problem, and therefore, an entirely different approach will be needed to modeling protein folding that encompasses the entire field, edge cases and all (a quite lofty goal that may also never be reached). Of course I'm fallible, but it doesn't change the fact that right now, this is the case - AlphaFold teaches us essentially nothing about how proteins are actually folding, and instead is solving for the folded state. If someone can backtrack from there, I'll be nothing but ecstatic.