3 ms·

The difficult part of it is: for some people it is literally nothing. We had it now for the fourth time since 2020 even though we’re properly vaccinated and car

by baxtr 4y ago

The difficult part of it is: for some people it is literally nothing. We had it now for the fourth time since 2020 even though we’re properly vaccinated and careful as much as life permits. It’s a bit worse than a cold but much better for than the flu. So, yes, for us life just goes on with COVID. No need to change anything.

autoexec 4y ago
That is a problem. It's a dice roll each time a person is infected depending on a huge number of factors including what strain they've been hit with. Reinfections can give worse odds each time. People who got lucky once or twice before might be more careless thinking their luck will continue and end up screwing themselves. https://www.webmd.com/lung/news/20220707/each-covid-19-reinfection-increases-health-risks https://www.webmd.com/lung/news/20220707/each-covid-19-reinf...
- Animats 4y ago
  "Reinfections can give worse odds each time." Not necessarily worse, but there is cumulative damage. In the UK, about 7% of COVID cases that get medical attention are now re-infections. That number increases with time; it was only 4% last February. Immunity from getting COVID is time-limited and not that long. One study said "time between reinfections ranged from 90 to 650 days, with the average being 343 days". Over a decade, this might gradually debilitate most of the population.
  - autoexec 4y ago
    I'm hoping that over the coming decade we get better defenses. Improved vaccines, treatments, and a greater understanding of the virus could prevent a lot of that harm. It hasn't been long enough to see what the long term consequences of infections or even our vaccines and current treatments will be for that matter, but I'll stay up to date on vaccines and continue taking sensible precautions against catching or spreading the virus. It's the best I can do to help my odds given what we know currently.
AnthonBerg 4y ago
There are many, many scientists who are attempting to warn us that isn’t nothing. The literature is piling up. Paper: Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection – https://doi.org/10.1038/s41590-021-01113-x https://doi.org/10.1038/s41590-021-01113-x Paper: “Excess risk for acute myocardial infarction mortality during the COVID-19 pandemic” — https://doi.org/10.1002/jmv.28187 https://doi.org/10.1002/jmv.28187 Paper: “p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)” — https://doi.org/10.3389/fphar.2022.871583 https://doi.org/10.3389/fphar.2022.871583 SARS-CoV-2 directly and indirectly interferes with p53 expression and balance. On p53: “p53, cellular tumor antigen p53 (UniProt name); p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.” — https://en.wikipedia.org/wiki/P53 https://en.wikipedia.org/wiki/P53 The literature goes on and on and on. People really are not okay after contracting this virus. I know plenty of people who simply are not recovering after COVID illness. Friends. Close family. Kids. We are being warned. And crucially: We can clean this crap out of the air. Nobody has to breathe in SARS-CoV-2. We absolutely must demand that something is done. There’s lots and lots that can be done.
- krater23 4y ago
  I would not wonder if you throw so much research time to a normal flu you will find similar things.
  - deleted 4y ago
    [deleted]
  - Animats 4y ago
    People do study that. There's known to be a significantly increased risk of heart attack and stroke in people who have recovered from influenza, but that risk returns to baseline after about two months. The big risk is in the first 7 days.[1] [1] https://www.nejm.org/doi/full/10.1056/NEJMoa1702090 https://www.nejm.org/doi/full/10.1056/NEJMoa1702090

by baxtr 4y ago

autoexec 4y ago

That is a problem. It's a dice roll each time a person is infected depending on a huge number of factors including what strain they've been hit with. Reinfections can give worse odds each time. People who got lucky once or twice before might be more careless thinking their luck will continue and end up screwing themselves. https://www.webmd.com/lung/news/20220707/each-covid-19-reinfection-increases-health-risks https://www.webmd.com/lung/news/20220707/each-covid-19-reinf...

Animats 4y ago
"Reinfections can give worse odds each time." Not necessarily worse, but there is cumulative damage. In the UK, about 7% of COVID cases that get medical attention are now re-infections. That number increases with time; it was only 4% last February. Immunity from getting COVID is time-limited and not that long. One study said "time between reinfections ranged from 90 to 650 days, with the average being 343 days". Over a decade, this might gradually debilitate most of the population.
- autoexec 4y ago
  I'm hoping that over the coming decade we get better defenses. Improved vaccines, treatments, and a greater understanding of the virus could prevent a lot of that harm. It hasn't been long enough to see what the long term consequences of infections or even our vaccines and current treatments will be for that matter, but I'll stay up to date on vaccines and continue taking sensible precautions against catching or spreading the virus. It's the best I can do to help my odds given what we know currently.

AnthonBerg 4y ago

There are many, many scientists who are attempting to warn us that isn’t nothing. The literature is piling up. Paper: Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection – https://doi.org/10.1038/s41590-021-01113-x https://doi.org/10.1038/s41590-021-01113-x Paper: “Excess risk for acute myocardial infarction mortality during the COVID-19 pandemic” — https://doi.org/10.1002/jmv.28187 https://doi.org/10.1002/jmv.28187 Paper: “p53/NF-kB Balance in SARS-CoV-2 Infection: From OMICs, Genomics and Pharmacogenomics Insights to Tailored Therapeutic Perspectives (COVIDomics)” — https://doi.org/10.3389/fphar.2022.871583 https://doi.org/10.3389/fphar.2022.871583 SARS-CoV-2 directly and indirectly interferes with p53 expression and balance. On p53: “p53, cellular tumor antigen p53 (UniProt name); p53 proteins are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.” — https://en.wikipedia.org/wiki/P53 https://en.wikipedia.org/wiki/P53 The literature goes on and on and on. People really are not okay after contracting this virus. I know plenty of people who simply are not recovering after COVID illness. Friends. Close family. Kids. We are being warned. And crucially: We can clean this crap out of the air. Nobody has to breathe in SARS-CoV-2. We absolutely must demand that something is done. There’s lots and lots that can be done.

krater23 4y ago
I would not wonder if you throw so much research time to a normal flu you will find similar things.
- deleted 4y ago
  [deleted]
- Animats 4y ago
  People do study that. There's known to be a significantly increased risk of heart attack and stroke in people who have recovered from influenza, but that risk returns to baseline after about two months. The big risk is in the first 7 days.[1] [1] https://www.nejm.org/doi/full/10.1056/NEJMoa1702090 https://www.nejm.org/doi/full/10.1056/NEJMoa1702090