There are massive python and bash codebases used at all of the major cloud service providers. And none of the cloud service providers are using custom-compiled

There are massive python and bash codebases used at all of the major cloud service providers. And none of the cloud service providers are using custom-compiled PGO-optimized OSes specifically optimized for the exact architecture and instruction set and resource set that they will be deployed on, despite >1% performance advantages for doing so. Because sometimes the complexity of doing things the fastest way possible is not worth the performance improvement. The boeing example is illuminating. One could conceive of infinite possibilities where it would be better to spend the extra million dollars than to get something that saved a pound but didn't meet other project requirements. What good would it be to buy a $1M cheaper 747 if the landing gear broke on each landing? Everything is a tradeoff, even things that are extremely important like weight on airplanes or runtime performance in computers.