If two photons are better than one, why not Doc Edgerton style "strobes"? Too much data generated? Too much energy required? Am finding it difficult to get use

If two photons are better than one, why not Doc Edgerton style "strobes"? Too much data generated? Too much energy required? Am finding it difficult to get useful unbiased quantitative measurements from two-photon excitation, cryo-em, etc. Alter the warp parameters, and the capillary branch network is altered. Not to mention what CV magic the STED-superresolution capture has baked in. Really useful for in vivo "movies". But you can't beat good slide prep, sota ccd capture, carl zeiss mag and statistical sampling. Fine cell structure determination down to angstrom limits can be estimated with only a few slices and proper design of experiments ;) https://www.leica-microsystems.com/products/confocal-microscopes/p/stellaris-sted/ https://www.leica-microsystems.com/products/confocal-microsc...