I think the state of the literature is a little more complicated than you surmise from Huberman's podcast. For example, note especially their careful wording ar

I think the state of the literature is a little more complicated than you surmise from Huberman's podcast. For example, note especially their careful wording around its neurotoxicity, as well as the clinical dosing assumptions they make their claims within, which likely differ from those of casual users. As a cautionary example, you should look into alpha-Methyldopamine. Last I checked (which was, admittedly, several years ago), there was not a good rebuttal to its neurotoxic potential. Though this potential is less serious than the neurotoxicity demonstrated by the botched study which injected methamphetamine and said it was MDMA (and was later corrected, but the damage to MDMA's reputation had already been done), I still think it demonstrates that the case of MDMA's neurotoxicity, at least in the way that a casual user might consume it--even sparingly--is not an open and shut case. That said, I'd love to be proven wrong, since MDMA is great stuff. I hope someone can check the most recent literature on this topic and tell me otherwise.