Another class of putatively non- or less-neurotoxic entactogens I don't see mentioned here are aminoindanes, which David Nichols' group specifically engineered

Another class of putatively non- or less-neurotoxic entactogens I don't see mentioned here are aminoindanes, which David Nichols' group specifically engineered to have lower neurotoxic potential. The classic prototype here is 5,6-methylenedioxy-2-aminoindane, or MDAI. It's also worth considering. The other broad classes of potentially non- or less-neurotoxic entactogens which I'm aware of, other than aminoindanes, are benzofurans (which are covered in the article) and substituted cathinones. Imo, all three classes contain molecules which are just peachy :) I recommend (prudent) exploration.