The safety track record has been very inconsistent for RCs. Shulgin's popular creations turned out to be very safe, even in overdose, besides the few that were

The safety track record has been very inconsistent for RCs. Shulgin's popular creations turned out to be very safe, even in overdose, besides the few that were MAOIs (2C-T-7 and AMT, off the top of my head.) But Shulgin was looking for good, safe psychedelics. David Nichols's lab worked in the same area, but focused on high-affinity 5-HT2A agonists. They made Bromo-DragonFLY (killed a few people after it was mislabeled as 2C-B-FLY), and then most recently the NBOMe series, which is often sold as counterfeit acid. NBOMes produce spectacular, rich visuals, and a strong euphoria uncharacteristic for the class. Unfortunately, they seem to kill people at random, for no good reason. Even people taking it again at the same dose. And it can happen very abruptly. Seems to be from seizures disrupting the autonomic nervous system. So chemical purity isn't the thing to worry about, it's the pharmacology. It's like test piloting experimental aircraft or something. If you experiment, use Shulgin's method and work up very, very slowly.