3 ms·
I don't really have a very high opinion of MDMA, it's basically just a modified amphetamine and the amphetamines have a not-so-great historical record, being mo
by photochemsyn 4y ago
I don't really have a very high opinion of MDMA, it's basically just a modified amphetamine and the amphetamines have a not-so-great historical record, being more likely to lead to addictive behavior. These modified molecules are all amphetamines - just look at the right-hand tail of the molecules in the images and compare to amphetamine.
https://en.wikipedia.org/wiki/Amphetamine https://en.wikipedia.org/wiki/Amphetamine
The paper cited on the potential similarity to psilocybin and LSD (which exert their activity through the 5-HT2A receptor) is behind a paywall and mice of course are not humans, so that's very speculative.
However, why mess around with compounds with unknown metabolic breakdown behavior, with unknown side effects and activity in humans, when the existing psychedelics (such as psilocybin, DMT, LSD and mescaline) are fairly well understood in terms of effects on humans?
- boring_twenties 4y agoPsilocybin, DMT, LSD and mescaline all have vastly different effects from MDMA. That's why MDMA is called an entactogen or empathogen, and not a psychedelic.
- vsef 4y agoMescaline is a substituted amphetamine just like MDMA. As is the antidepressant buproprion (Wellbutrin). And a variety of very strong hallucinogens.
- Synaesthesia 4y agoMDMA can be problematic like that, it has a host of side effects, particularly at higher doses and can be mildly habit forming. The effects also wane very rapidly with repeated use and the side effects become much worse. A valuable drug but one to use with caution. I would definitely stick to the below 120mg dosages, these pills with 220mg are way too much!