It's mostly a matter of discipline to not run back to what you're comfortable with to get used to unusual layouts. They will become second nature to you if you

It's mostly a matter of discipline to not run back to what you're comfortable with to get used to unusual layouts. They will become second nature to you if you use them long enough. I am not suggesting that you must do this, mind you. Just that you almost certainly could get used to it if you forced yourself to. The benefits of doing so may not be worthwhile, though.