> My spouse is 39 so the window has closed for biological children, more or less. Not necessarily. My wife was in her late 30s when we had our (and her, and my

> My spouse is 39 so the window has closed for biological children, more or less. Not necessarily. My wife was in her late 30s when we had our (and her, and my) first kid, and just shy of 40 when we had our second. Yes, older mothers are at somewhat-greater risk of things like Down's Syndrome, but both our kids are now in their early 30s, quite-normal adults with S.O.s of their own. So talk to your wife — and (as Dear Abby always says) also talk to a licensed mental health professional as well: As others have noted, you might well have something else going on that you're interpreting as regret over childlessness.