This is the correct answer. GoF has, and has had for years, a very narrow and specific meaning when applied to virology. This is not some arbitrary meaning, but

This is the correct answer. GoF has, and has had for years, a very narrow and specific meaning when applied to virology. This is not some arbitrary meaning, but rather is used by funding and regulatory agencies to evaluate risk. Gain of function as described, has to increase the virulence of a potential human pandemic-causing pathogen. To those who might counter that this definition needs to be changed: I don't disagree, but until it is, scientists are going to grade themselves on the scales they are given by the funding and regulatory agencies.