2 ms·
Correct. See for example: https://journals.asm.org/doi/10.1128/mbio.03617-21 https://journals.asm.org/doi/10.1128/mbio.03617-21 "These data suggest that virt
by lamontcg 4y ago
Correct.
See for example:
https://journals.asm.org/doi/10.1128/mbio.03617-21 https://journals.asm.org/doi/10.1128/mbio.03617-21
"These data suggest that virtually all individuals with existing anti-SARS-CoV-2 CD8+ T-cell responses should recognize the Omicron VOC and that SARS-CoV-2 has not evolved extensive T-cell escape mutations at this time."
https://www.nature.com/articles/s41423-022-00838-5 https://www.nature.com/articles/s41423-022-00838-5
"Although the Omicron variant escapes neutralizing antibodies induced by COVID-19 vaccination or natural infection [1,2,3], our current analysis demonstrates that T cell epitopes are considerably conserved in the Omicron variant and that substantial proportions of memory T cells elicited by COVID-19 vaccination or natural infection respond to the Omicron spike. These results indicate that memory T cells may provide protective immunity during reinfection or breakthrough infection with the Omicron variant."
Here's a review of all the SARS-CoV-2 T-cell epitopes:
https://www.sciencedirect.com/science/article/pii/S1931312821002389 https://www.sciencedirect.com/science/article/pii/S193131282...
"Here, we focus on a specific topic: our current knowledge concerning the definition and recognition of SARS-CoV-2-derived T cell epitopes in humans. While the data related to this topic was initially sparse, 25 different studies have now been published as of March 15, 2021 [...], which collectively report data from 1,197 human subjects (870 COVID-19 and 327 unexposed controls), leading to the identification of over 1,400 different CD4 (n = 382) and CD8 (n = 1052) T cell epitopes."
And I'd highly recommend this video on the adaptive immune system, along with the whole rest of the series:
https://www.youtube.com/watch?v=dXL2TvhNqZI&list=PLGhmZX2NKiNm0vqVhoYB_xZP6E6tGT6rU https://www.youtube.com/watch?v=dXL2TvhNqZI&list=PLGhmZX2NKi...
(I think that covers how proteins get chopped up by proteases and then those short epitopes are displayed on MHC receptors and undifferentiated T-cells learn to identify them)