3 ms·

I'd recommend deleting or editing your comment. The actual definition of "gain-of-function" is quite easy to find if you want to take this matter seriously: htt

I'd recommend deleting or editing your comment. The actual definition of "gain-of-function" is quite easy to find if you want to take this matter seriously: https://en.wikipedia.org/wiki/Gain-of-function_research https://en.wikipedia.org/wiki/Gain-of-function_research

Kranar 4y ago
I'm no expert but it seems from the comments and the Wikipedia article you link to that OPs position isn't that far from the truth, certainly not so blatantly false that it warrants editing or deleting. The article you linked to says gain of function research is "medical research that genetically alters an organism in a way that may enhance the biological functions of gene products", which seems like a more technical way of saying what OP said. The example Wikipedia gives explicitly states specifies, and I quote, a "situation would be considered a gain-of-function experiment, as the virus did not previously have that function." The journal Nature states that gain of function is "GOF is a classic genetics term to describe mutations that give a gene, RNA or protein new abilities". Not much different from what OP stated, unless there is a nuance you wish to point out: https://www.nature.com/articles/d41586-021-02903-x https://www.nature.com/articles/d41586-021-02903-x NIH's website states gain of function (as well as loss of function) research is any selection process involving the alteration of a genotype in order to produce a corresponding change in phenotype: https://www.ncbi.nlm.nih.gov/books/NBK285579 https://www.ncbi.nlm.nih.gov/books/NBK285579 That is a much more technical way of saying gain of function research is what happens when you modify genes to produce a change in phenotype, which is the technical term for the observable behavior and characteristics of an organism, ie. function. So anyhow, it's possible OP is wrong, Wikipedia is wrong, and a host of comments/sources are wrong, in fact it may very well be likely, but without a better source available it does seem like gain of function research is fairly open-ended research that attempts to modify an organism's genetics so as to add additional functions that it did not otherwise have.
Vecr 4y ago
I stand by my statement.

Kranar 4y ago

I'm no expert but it seems from the comments and the Wikipedia article you link to that OPs position isn't that far from the truth, certainly not so blatantly false that it warrants editing or deleting. The article you linked to says gain of function research is "medical research that genetically alters an organism in a way that may enhance the biological functions of gene products", which seems like a more technical way of saying what OP said. The example Wikipedia gives explicitly states specifies, and I quote, a "situation would be considered a gain-of-function experiment, as the virus did not previously have that function." The journal Nature states that gain of function is "GOF is a classic genetics term to describe mutations that give a gene, RNA or protein new abilities". Not much different from what OP stated, unless there is a nuance you wish to point out: https://www.nature.com/articles/d41586-021-02903-x https://www.nature.com/articles/d41586-021-02903-x NIH's website states gain of function (as well as loss of function) research is any selection process involving the alteration of a genotype in order to produce a corresponding change in phenotype: https://www.ncbi.nlm.nih.gov/books/NBK285579 https://www.ncbi.nlm.nih.gov/books/NBK285579 That is a much more technical way of saying gain of function research is what happens when you modify genes to produce a change in phenotype, which is the technical term for the observable behavior and characteristics of an organism, ie. function. So anyhow, it's possible OP is wrong, Wikipedia is wrong, and a host of comments/sources are wrong, in fact it may very well be likely, but without a better source available it does seem like gain of function research is fairly open-ended research that attempts to modify an organism's genetics so as to add additional functions that it did not otherwise have.

Vecr 4y ago

I stand by my statement.