The paper Title is >Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron< >Omicron, efficiently replicates in cell lines and prima

The paper Title is >Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron< >Omicron, efficiently replicates in cell lines and primary-like distal lung cells. In *K18-hACE2 Mice* , while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. This indicates that while the vaccine escape of Omicron is defined by mutations in S, major determinants of viral pathogenicity reside outside of S.