I agree that there's a big difference between "domestication" (that we've done with dogs) and breeding for intelligence. I'm not aware that we're doing that wit

I agree that there's a big difference between "domestication" (that we've done with dogs) and breeding for intelligence. I'm not aware that we're doing that with any species (except for maybe Harvard Grads). Also, one of the conceits of the "Uplift saga" is that genetic engineering tweaks cause most of the "uplift." It's also interesting to note that one of the first species "uplifted" are dolphins, a species that doesn't have much chance to annoy/outcompete humans. I guess it boils down to how important "intelligence" is to evolutionary adaptation. It apparently conferred significant reproductive benefit to humans (the most populous primate species). OTOH, to quote J.S.B. Haldane: "the Creator, if he exists, has a inordinate fondness for beetles."