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And then someone will come in and tell you that most things tried in mice don't work out in humans, and we will issue a collective shrug as we don't know what t
by civilized 4y ago
And then someone will come in and tell you that most things tried in mice don't work out in humans, and we will issue a collective shrug as we don't know what to believe.
- csdvrx 4y agoWhat doesn't work in mice is typically for mouse-models of diseases: we try to replicate a disease based on what we think causes it, then try to cure it. That's typical for cancer, Alzheimer etc. No wonder the things tried in the toy problem don't work out when faced with the real problem! The problem isn't so much the mice being so different, but the disease itself being very different from the toy problem.
- civilized 4y agoSo how is the enhancer mouse research different from the disease mouse research that you acknowledge often doesn't work?
- ethanbond 4y agoThe nice thing is that you don't need to decide what to believe. You just keep doing experiments and, if well designed, they'll tell you what's true anyway. These animal model experiments are not intended to prove applicability to humans, they're intended to prove that you can take the next (tiny) step along the (extremely long) road to human applicability.
- glenstein 4y agoWhich in and of itself is sufficient to proceed with "huh, cool! keep up this line of research!"
- gfodor 4y agoMice shedding