3 ms·
Were the drinks good? Less hangover inducing?
by robk 4y ago
Were the drinks good? Less hangover inducing?
- perihelions 4y agoRegarding the deuterated version, it's actually possible it would have very different pharmacokinetics to normal ethanol. The first step in metabolism involves breaking the -O-H bond to create the =O aldehyde, so replacing that with a heaver -O-D would have a kinetic effect. For example, here's a Derek Lowe article about deuterated drugs (not ethanol): - "So a well placed deuterium (or two, or three) can actually have a significant effect on how long a drug will circulate in the bloodstream, by slowing down the liver's clearance mechanism." https://www.science.org/content/blog-post/first-deuterated-drug-arrives https://www.science.org/content/blog-post/first-deuterated-d... ("The First Deuterated Drug Arrives")
- skykooler 4y agoSomething to keep in mind is that since normal hydrogen is about 0.1% deuterium, all hydrogen-containing molecules end up also 0.1% deuterated by default - so the effects of a deuterated molecule can only differ from the normal to the point that in 0.1% concentration it would not be noticed.