3 ms·

The MSDS for that jar of peanut butter says it's not an asphyxiant... as someone with peanut allergy, I beg to differ ;) Nice submission. Brings back memories

The MSDS for that jar of peanut butter says it's not an asphyxiant... as someone with peanut allergy, I beg to differ ;) Nice submission. Brings back memories of making alcoholic drinks from expensive spectroscopy grade ethanol. We never dared hitting the deuterated ethanol for NMR purposes...

robk 4y ago
Were the drinks good? Less hangover inducing?
- perihelions 4y ago
  Regarding the deuterated version, it's actually possible it would have very different pharmacokinetics to normal ethanol. The first step in metabolism involves breaking the -O-H bond to create the =O aldehyde, so replacing that with a heaver -O-D would have a kinetic effect. For example, here's a Derek Lowe article about deuterated drugs (not ethanol): - "So a well placed deuterium (or two, or three) can actually have a significant effect on how long a drug will circulate in the bloodstream, by slowing down the liver's clearance mechanism." https://www.science.org/content/blog-post/first-deuterated-drug-arrives https://www.science.org/content/blog-post/first-deuterated-d... ("The First Deuterated Drug Arrives")
  - skykooler 4y ago
    Something to keep in mind is that since normal hydrogen is about 0.1% deuterium, all hydrogen-containing molecules end up also 0.1% deuterated by default - so the effects of a deuterated molecule can only differ from the normal to the point that in 0.1% concentration it would not be noticed.
metaphor 4y ago
> The MSDS for that jar of peanut butter says it's not an asphyxiant... as someone with peanut allergy, I beg to differ ;) Just in case the sarcasm wasn't abundantly obvious, the precise term used was simple asphyxiant with the following regulatory meaning[1]: >> Simple asphyxiant means a substance or mixture that displaces oxygen in the ambient atmosphere, and can thus cause oxygen deprivation in those who are exposed, leading to unconsciousness and death. [1] https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1200 https://www.osha.gov/laws-regs/regulations/standardnumber/19...
perihelions 4y ago
That'd be one expensive cocktail. Always remember to drink in (neutron) moderation!
collegeburner 4y ago
i'd be curious how a deuterated cocktail would taste. a few people have consumed heavy water and it tastes sweet, i wonder if this carries over to ethanol. naturally no sugar added!

robk 4y ago

Were the drinks good? Less hangover inducing?

perihelions 4y ago
Regarding the deuterated version, it's actually possible it would have very different pharmacokinetics to normal ethanol. The first step in metabolism involves breaking the -O-H bond to create the =O aldehyde, so replacing that with a heaver -O-D would have a kinetic effect. For example, here's a Derek Lowe article about deuterated drugs (not ethanol): - "So a well placed deuterium (or two, or three) can actually have a significant effect on how long a drug will circulate in the bloodstream, by slowing down the liver's clearance mechanism." https://www.science.org/content/blog-post/first-deuterated-drug-arrives https://www.science.org/content/blog-post/first-deuterated-d... ("The First Deuterated Drug Arrives")
- skykooler 4y ago
  Something to keep in mind is that since normal hydrogen is about 0.1% deuterium, all hydrogen-containing molecules end up also 0.1% deuterated by default - so the effects of a deuterated molecule can only differ from the normal to the point that in 0.1% concentration it would not be noticed.

metaphor 4y ago

> The MSDS for that jar of peanut butter says it's not an asphyxiant... as someone with peanut allergy, I beg to differ ;) Just in case the sarcasm wasn't abundantly obvious, the precise term used was simple asphyxiant with the following regulatory meaning[1]: >> Simple asphyxiant means a substance or mixture that displaces oxygen in the ambient atmosphere, and can thus cause oxygen deprivation in those who are exposed, leading to unconsciousness and death. [1] https://www.osha.gov/laws-regs/regulations/standardnumber/1910/1910.1200 https://www.osha.gov/laws-regs/regulations/standardnumber/19...

perihelions 4y ago

That'd be one expensive cocktail. Always remember to drink in (neutron) moderation!

collegeburner 4y ago

i'd be curious how a deuterated cocktail would taste. a few people have consumed heavy water and it tastes sweet, i wonder if this carries over to ethanol. naturally no sugar added!