3 ms·

Drugs can give you the insight to change your perspective though. From my understanding, depression is a deadly spiral of mental state leading to chemical imbal

Drugs can give you the insight to change your perspective though. From my understanding, depression is a deadly spiral of mental state leading to chemical imbalance which further reinforces the mental state, making it impossible to see outside that worldview. Thus drugs can take you out of that cycle and give a glimpse outside, and then even after the drug wears off the change in perspective is persistent.

skissane 4y ago
> From my understanding, depression is a deadly spiral of mental state leading to chemical imbalance There has never been any good scientific evidence that depression (or any other mental health issue for that matter) involves a “chemical imbalance”. It is, at the very best, a debatable and unproven hypothesis - yet many think it is some proven fact. To pick out just a couple of the numerous sources which confirm this, see https://www.nature.com/articles/s41380-022-01661-0 https://www.nature.com/articles/s41380-022-01661-0 and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277931/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277931/
- scotty79 4y ago
  My personal belief is that depression is a deadly spiral stemming from and exacerbating damage to neurons.
- gjvnq 4y ago
  > There has never been any good scientific evidence that depression (or any other mental health issue for that matter) involves a “chemical imbalance”. Transfem here. Gender Dysphoria is a hell of a condition and it usually improves massively as soon as people start taking cross-sex hormonal replacement therapy (HRT). In my personal experience, it was almost like magic how quickly and how much I improved when my testosterone finally fell to zero.
  - skissane 4y ago
    You’ve wanted something for years and now at last you are getting it - that fact alone has to make a person feel happier and feel like the trajectory of their life is turning in a more positive direction. It is near impossible to determine what consequences of cross-sex HRT are due to its direct biochemical effects, and which are due to those kinds of psychological factors.

skissane 4y ago

> From my understanding, depression is a deadly spiral of mental state leading to chemical imbalance There has never been any good scientific evidence that depression (or any other mental health issue for that matter) involves a “chemical imbalance”. It is, at the very best, a debatable and unproven hypothesis - yet many think it is some proven fact. To pick out just a couple of the numerous sources which confirm this, see https://www.nature.com/articles/s41380-022-01661-0 https://www.nature.com/articles/s41380-022-01661-0 and https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277931/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1277931/

scotty79 4y ago
My personal belief is that depression is a deadly spiral stemming from and exacerbating damage to neurons.
gjvnq 4y ago
> There has never been any good scientific evidence that depression (or any other mental health issue for that matter) involves a “chemical imbalance”. Transfem here. Gender Dysphoria is a hell of a condition and it usually improves massively as soon as people start taking cross-sex hormonal replacement therapy (HRT). In my personal experience, it was almost like magic how quickly and how much I improved when my testosterone finally fell to zero.
- skissane 4y ago
  You’ve wanted something for years and now at last you are getting it - that fact alone has to make a person feel happier and feel like the trajectory of their life is turning in a more positive direction. It is near impossible to determine what consequences of cross-sex HRT are due to its direct biochemical effects, and which are due to those kinds of psychological factors.