3 ms·
Covid – Oxford/AstraZeneca Nasal Spray Vaccine Poor Trial Results
- ggm 4y agoBut not all nasal vaccines: just this one. As the article says, they need to try a reformulation to try and make it "stick" to nasal mucosa and not get swallowed. Or, move to an asthma inhaler type model.
- Trouble_007 4y ago>But not all nasal vaccines< -- True! Perhaps a two stage nasal inoculation is required, maybe one squirt of vaccine, plus mucous membrane penetrator, followed by a second squirt of vaccine, plus mucous membrane sealer. search: >'intranasally administered heparin'< @DDG : <https://html.duckduckgo.com/html/?q='intranasally administered heparin' https://html.duckduckgo.com/html/?q='intranasally administer...>
- Trouble_007 4y agoTolerability and immunogenicity of an intranasally-administered adenovirus-vectored COVID-19 vaccine An open-label partially-randomised ascending dose phase I trial : https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00480-7/fulltext https://www.thelancet.com/journals/ebiom/article/PIIS2352-39... search: >'intranasally administered COVID-19 vaccine'< @DDG : <https://html.duckduckgo.com/html/?q='intranasally administered COVID-19 vaccine' https://html.duckduckgo.com/html/?q='intranasally administer...>