I used an Akitio Node 3 with RX580 for years, works fine on macOS, Linux and Windows on both Thunderbolt 2 (reduced performance) and Thunderbolt 3. Only reason

I used an Akitio Node 3 with RX580 for years, works fine on macOS, Linux and Windows on both Thunderbolt 2 (reduced performance) and Thunderbolt 3. Only reason I stopped using it is because I used it less and had more use for it on Linux than anywhere else, so it's permanently installed in a Linux desktop machine now. It works passthrough to a Windows VM as well. The Intel Mac it was connected to is no longer used with more than 2 displays so the internal GPU works well enough, and an M1 has no problems with it either. For the time where I used it, it was a perfect solution for me; lots of portable use, but when working from home more the portability aspect isn't worth much. Add to that that GPU usage on-the-go is pretty much gone for me (most GPU workloads just run on AWS for me now), and having a high-power GPU connected to a laptop just doesn't help me with anything. If in the future I'd need more local GPU power than a mobile device (in a form factor I enjoy) can handle, maybe it'll be interesting again. Have one at home, another at an office, only move the laptop between places...