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I haven't found any clients that can handle replying with wildcard aliases, which is a feature I use several times a day. If anyone has a recommendation, I'd be

• beagle3 4y ago
  Thunderbird has had it for ages - you do need to pick it from the menu (“customize from address”) for completely free form. You can also set up multiple identities to pick from for the more frequent addresses you use; I set up the 6 most used, and now only need to use the “customize..l option about once a week (compared to several a day before, like you)
• nikau 4y ago
  I use outlook which lets you set the from address as required.