4 ms·

Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends

Previous links and discussions on Rapamycin and Metformin: Rapamycin, drug used in cancer therapy, emerges as powerful anti-aging remedy [1] Rapamycin extends life span and health span of male mice and Daphnia magna [2] Drug typically used in cancer therapy emerges as potential anti-aging treatment[3] Diabetes Drug Metformin Reduces All-Cause Mortality and Diseases of Aging (2017)[4] Metformin for cancer prevention, longevity: popular in Silicon Valley[5] [1] https://news.ycombinator.com/item?id=32660669 https://news.ycombinator.com/item?id=32660669 [2] https://news.ycombinator.com/item?id=33058322 https://news.ycombinator.com/item?id=33058322 [3] https://news.ycombinator.com/item?id=32648886 https://news.ycombinator.com/item?id=32648886 [4] https://news.ycombinator.com/item?id=27486841 https://news.ycombinator.com/item?id=27486841 [5] https://news.ycombinator.com/item?id=19472942 https://news.ycombinator.com/item?id=19472942

ChrisGranger 4y ago
My understanding is that Metformin's mortality reduction effect is only present in younger people. I don't have a source handy, but I take it for diabetes and was reading about its other positive effects a few years ago. Perhaps someone can chime in with additional information.
- graderjs 4y ago
  I'm interested in how ultra-low-dose (or "sparse" regimens) affect things (before you get triggered by homeopathy, I'm not making regard to that here..tho doesn't mean in some cases it can't be effective). For example, ultra low dose minoxidil (a blood pressure drug) reverses hair loss in many people (not if you're totally bald, but in thinning areas) at dosages where it's "on-label" effect (lowering blood pressure) doesn't even occur. I wonder how ultra-low-dose (or sparse, like "1 timer per quarter") metformin affects things. I can't recall the compound now, but I recall seeing something the other day about: "encounter with compound X just one time permanently strengthens immune system" or something. I think it was also in mice. I'm not even sure it was "immune system". Also want to note that: our current pharmaceutical industry of (mostly) single molecule therapies is just one slice of the pie. In the future, we will probably have access to therapies that seem really sophisticated: not just "concoctions" (of multiple compounds in one therapy, which currently we are not sophisticated enough to explore sufficiently so the space of possible interactions that are therapeutic remains unknown); but also more "active" therapies, that include some vector (like virus, protein molecular machine, funghi, bacteria) that help to deliver / manufacture the therapy to just the right: time, location, amount our body needs. And rather than being a specialized minority, they will be the majority. I think the space of molecules that are effective when delivered "systemically" is not as large or contains as many "silver bullet therapies" as the space of therapies that is effective when delivered precisely.
graderjs 4y ago
Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medicines"
- jokowueu 4y ago
  You won't do it at the same doses as cancer treatment protocols . I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .
  - graderjs 4y ago
    Would be interested in your experience with fluorometholone eye drops. On-label for itchy eyes, but off-label seems to rapidly (onset ~ 60 seconds) reduce brain inflammation temporarily leading to mental quiet. Can't use too much tho as the steroid will dull the immune system in your sinuses increasing infection risk.
    - jokowueu 4y ago
      I have never used it but just like you explained Steroids will have that effect You can join the discord server run by joshua leisk and mention fluorometholone and I'll find you so we can see what might best work for you https://discord.gg/2HwvnxEn https://discord.gg/2HwvnxEn
  - airza 4y ago
    I don’t know how to ask this neutrally, but how did you (and a doctor?) come to use an anti cancer medication for mood stabilization?
    - 4y ago

ChrisGranger 4y ago

My understanding is that Metformin's mortality reduction effect is only present in younger people. I don't have a source handy, but I take it for diabetes and was reading about its other positive effects a few years ago. Perhaps someone can chime in with additional information.

graderjs 4y ago
I'm interested in how ultra-low-dose (or "sparse" regimens) affect things (before you get triggered by homeopathy, I'm not making regard to that here..tho doesn't mean in some cases it can't be effective). For example, ultra low dose minoxidil (a blood pressure drug) reverses hair loss in many people (not if you're totally bald, but in thinning areas) at dosages where it's "on-label" effect (lowering blood pressure) doesn't even occur. I wonder how ultra-low-dose (or sparse, like "1 timer per quarter") metformin affects things. I can't recall the compound now, but I recall seeing something the other day about: "encounter with compound X just one time permanently strengthens immune system" or something. I think it was also in mice. I'm not even sure it was "immune system". Also want to note that: our current pharmaceutical industry of (mostly) single molecule therapies is just one slice of the pie. In the future, we will probably have access to therapies that seem really sophisticated: not just "concoctions" (of multiple compounds in one therapy, which currently we are not sophisticated enough to explore sufficiently so the space of possible interactions that are therapeutic remains unknown); but also more "active" therapies, that include some vector (like virus, protein molecular machine, funghi, bacteria) that help to deliver / manufacture the therapy to just the right: time, location, amount our body needs. And rather than being a specialized minority, they will be the majority. I think the space of molecules that are effective when delivered "systemically" is not as large or contains as many "silver bullet therapies" as the space of therapies that is effective when delivered precisely.

graderjs 4y ago

Rapamycin side effects don't look great tho: https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects https://en.wikipedia.org/wiki/Sirolimus#Adverse_effects I prefer drugs that are: well-tolerated, cheap, already have a long history of use for conditions X, Y and Z, and then discovered as an off-label therapy (maybe in combination) for something else. As a heuristic it may not always work, but I think a good sign / rule-of-thumb might be "on the WHO list of essential medicines"

jokowueu 4y ago
You won't do it at the same doses as cancer treatment protocols . I've been doing rapa for my mood issues stemming from inflammation for some years now and low doses similar to the doses seen in recent studies for age longevity with no apparent side effects .
- graderjs 4y ago
  Would be interested in your experience with fluorometholone eye drops. On-label for itchy eyes, but off-label seems to rapidly (onset ~ 60 seconds) reduce brain inflammation temporarily leading to mental quiet. Can't use too much tho as the steroid will dull the immune system in your sinuses increasing infection risk.
  - jokowueu 4y ago
    I have never used it but just like you explained Steroids will have that effect You can join the discord server run by joshua leisk and mention fluorometholone and I'll find you so we can see what might best work for you https://discord.gg/2HwvnxEn https://discord.gg/2HwvnxEn
- airza 4y ago
  I don’t know how to ask this neutrally, but how did you (and a doctor?) come to use an anti cancer medication for mood stabilization?
  - 4y ago