3 ms·
> Prostate cancer is, from what I understand, one of the cancers with the least amount of genetic differences from normal tissue. Would love to find any refere
by dominotw 4y ago
> Prostate cancer is, from what I understand, one of the cancers with the least amount of genetic differences from normal tissue.
Would love to find any references for this.
FDA has only approved BRCA+ and few others like PALB2 for genetic targeting. It doesn't really matter how many others mutations that are found they won't be targeted with PARP.
So the question becomes is PC less likely to have target-able mutations compared to others ?
- 01100011 4y agohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073096/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073096/ > At a broad glance, prostate tumors have, on average, fewer mutations (0.7 per Mb) than other common cancers, such as breast (1.2 per Mb), bladder (7.1 per Mb), colorectal (3.1 per Mb), and melanoma (12.1 per Mb) I can't find the original article in which I saw it stated that PC has a lower mutational burden but the above might be sufficient.