I think it might be part of it! I also think it might be due to an effect on the Sigma-1 receptor. I can’t elucidate it further, I can only recall glimpses of i

I think it might be part of it! I also think it might be due to an effect on the Sigma-1 receptor. I can’t elucidate it further, I can only recall glimpses of insight from papers I was reading a while back. I only remember one title at the moment. Warning: EXTREMELY handwavy and speculative! Chronic activation of sigma-1 receptor evokes nociceptive activation of trigeminal nucleus caudalis in rats – https://doi.org/10.1016/j.pbb.2014.06.023 https://doi.org/10.1016/j.pbb.2014.06.023 My extremely speculative guess wrapped in hunch clad in doubt is that, well, as a premise, 5-HT2A activation due to psychedelics causes downregulation of that same receptor (5-HT2A). This is known and accepted afaik. And: The 5-HT2A receptor seems to be intimately related to the Sigma-1 receptor – and the Sigma-1 receptor is inside cells – so potentially it is the downregulation of the “outside” 5-HT2A receptor that then allows the Sigma-1 receptor set to get a bit of a break? Edit: Thing is, word on the street for literally decades has been that LSD and psilocybin help with migraine and cluster headaches. Finally there has been a study on it, which confirms the effect (to a certain degree; it’s a small preliminary study): Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin (2020) – https://doi.org/10.1007/s13311-020-00962-y https://doi.org/10.1007/s13311-020-00962-y