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These are great links, and answer many of the questions that I had. But there must be something more to the story; PhyloD is from 2007 and the news article is f
by carbocation 15y ago
These are great links, and answer many of the questions that I had. But there must be something more to the story; PhyloD is from 2007 and the news article is from 2011. Tangentially related, the research article that you linked is cited by a paper in PNAS that describes extraordinarily constrained coevolving group of sites in HIV (which appears to be a site of protein-protein interaction in the Gag protein). Such a group is likely a good target for multiple simultaneous therapeutics, as multiple mutations there likely reduce HIV's intrinsic fitness: http://www.pnas.org/content/108/28/11530.full http://www.pnas.org/content/108/28/11530.full
- kevinalexbrown 15y agoI was confused about the dates as well. It might be that this specific collaboration is new, but I don't really follow HIV in particular.
- ephermata 15y agoChecking David Heckerman's web page shows this paper from October 2011 in the Journal of Virology. I don't know how it relates to the news article specifically but it's interesting if you'd like to follow this stream of work. http://jvi.asm.org/content/early/2011/10/20/JVI.05577-11.abstract http://jvi.asm.org/content/early/2011/10/20/JVI.05577-11.abs... (Disclosure: I work at Microsoft Research, but not on this project.)