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I wonder if the anti inflammatory effects explain the mechanism of why Ergotamine is prescribed for migraines and cluster headaches! [0]. [0] https://en.wikipe

I wonder if the anti inflammatory effects explain the mechanism of why Ergotamine is prescribed for migraines and cluster headaches! [0]. [0] https://en.wikipedia.org/wiki/Ergotamine#Medical_uses https://en.wikipedia.org/wiki/Ergotamine#Medical_uses (Many years ago I remember a reddit post of a college student who used his school's lab to convert Ergotamine tablets into LSD and lay blotter. The comments were mostly of people congratulating him for his skill and then telling him to remove his post before he was discovered.)

AnthonBerg 4y ago
I think it might be part of it! I also think it might be due to an effect on the Sigma-1 receptor. I can’t elucidate it further, I can only recall glimpses of insight from papers I was reading a while back. I only remember one title at the moment. Warning: EXTREMELY handwavy and speculative! Chronic activation of sigma-1 receptor evokes nociceptive activation of trigeminal nucleus caudalis in rats – https://doi.org/10.1016/j.pbb.2014.06.023 https://doi.org/10.1016/j.pbb.2014.06.023 My extremely speculative guess wrapped in hunch clad in doubt is that, well, as a premise, 5-HT2A activation due to psychedelics causes downregulation of that same receptor (5-HT2A). This is known and accepted afaik. And: The 5-HT2A receptor seems to be intimately related to the Sigma-1 receptor – and the Sigma-1 receptor is inside cells – so potentially it is the downregulation of the “outside” 5-HT2A receptor that then allows the Sigma-1 receptor set to get a bit of a break? Edit: Thing is, word on the street for literally decades has been that LSD and psilocybin help with migraine and cluster headaches. Finally there has been a study on it, which confirms the effect (to a certain degree; it’s a small preliminary study): Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin (2020) – https://doi.org/10.1007/s13311-020-00962-y https://doi.org/10.1007/s13311-020-00962-y

AnthonBerg 4y ago

I think it might be part of it! I also think it might be due to an effect on the Sigma-1 receptor. I can’t elucidate it further, I can only recall glimpses of insight from papers I was reading a while back. I only remember one title at the moment. Warning: EXTREMELY handwavy and speculative! Chronic activation of sigma-1 receptor evokes nociceptive activation of trigeminal nucleus caudalis in rats – https://doi.org/10.1016/j.pbb.2014.06.023 https://doi.org/10.1016/j.pbb.2014.06.023 My extremely speculative guess wrapped in hunch clad in doubt is that, well, as a premise, 5-HT2A activation due to psychedelics causes downregulation of that same receptor (5-HT2A). This is known and accepted afaik. And: The 5-HT2A receptor seems to be intimately related to the Sigma-1 receptor – and the Sigma-1 receptor is inside cells – so potentially it is the downregulation of the “outside” 5-HT2A receptor that then allows the Sigma-1 receptor set to get a bit of a break? Edit: Thing is, word on the street for literally decades has been that LSD and psilocybin help with migraine and cluster headaches. Finally there has been a study on it, which confirms the effect (to a certain degree; it’s a small preliminary study): Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin (2020) – https://doi.org/10.1007/s13311-020-00962-y https://doi.org/10.1007/s13311-020-00962-y