Yes! Although not for CUDA. I used opencl. nixgl helped here: https://github.com/guibou/nixGL https://github.com/guibou/nixGL. CUDA should be even simpler since

Yes! Although not for CUDA. I used opencl. nixgl helped here: https://github.com/guibou/nixGL https://github.com/guibou/nixGL. CUDA should be even simpler since you just add the CUDA .so paths to the RPATH. Allthough I might be missing something. Custom libc might be a whole can of worms though if it happens to be incompatible.