I'm not aware of any major discoveries that have come about from this technique. Can someone correct me? I'd accept: - elucidating a new signal transduction

I'm not aware of any major discoveries that have come about from this technique. Can someone correct me? I'd accept: - elucidating a new signal transduction pathway - discovering an uncharacterized enzyme - measuring a biochemical constant of a known molecule (Kd e.g.) - discovering a new drug target that then gets exploited