I agree with this. There are novel tryptamines that exist that bind to 5HT2A but don't cause a trip. I've tried a couple of them. They do have effects upon mood

I agree with this. There are novel tryptamines that exist that bind to 5HT2A but don't cause a trip. I've tried a couple of them. They do have effects upon mood, generally positive, but they are distinctly different than the effects on mood from an actual trip. I think the difference comes from the meaning and significance that come from the experience of the trip itself. The meaning is logically and emotionally interwoven with your perspective, effectively changing it. I believe experience is required for that profound perspective shift, and non-psychedelic 5HT2A agonists don't provide that experience.