4 ms·
The probably strongest and most selective currently known 5ht2a agonist, 25I-NBOMe, is a psychedelic, and also (unlike LSD, which is less strong and less select
by tpm 4y ago
The probably strongest and most selective currently known 5ht2a agonist, 25I-NBOMe, is a psychedelic, and also (unlike LSD, which is less strong and less selective), much much more toxic and user reports say that the effects, both on body and mind, are much worse. So this is a complicated topic and I look forward to reading user reports from these new molecules, if they decide to test them.
- gavinray 4y agoEh, I wouldn't call the mental effects of NBOMe's objectively worse than say LSD -- just different Now, the body load/vasoconstriction + other physical effects, definitely. You can always tell the NBOMe is kicking in when you get shuttery cold from vasoconstriction and have a weird motor rigidity. Also FWIW, there are more potent agonists than NBOMe. I know of at least one discovered by Nichols' lab that they refused to publish for fear of use as an aerosolized bio-weapon.