4 ms·

[citation needed]

• rippercushions 4y ago
  There is significant evidence that MDMA, LSD and psilocybin, which are all psychedelic drugs but wildly different chemically, have a significant impact on depression. https://en.wikipedia.org/wiki/Psychedelic_therapy https://en.wikipedia.org/wiki/Psychedelic_therapy
  • waffleiron 4y ago
    Every single one of these has an effect on serotonin receptors, there are a lot of clinical antidepressants that don’t make you trip but affect serotonin. So I don’t think this is actually proof of the trip being needed
    • eurasiantiger 4y ago
      There’s also some evidence that those serotonergic antidepressants actually worsen depression and make it chronic.
      • deleted 4y ago
        [deleted]
    • rippercushions 4y ago
      The difference is that antidepressants have a temporary effect on serotonin levels and thus need to be taken continuously, while a "trip" on psychedelics appears to actually be able to rewire your brain, so a single dose can have permanent or at least much more long-lasting effects.