Before recently most GLP-1 agonists only gave a small amount of weight loss, and they've typically only been approved for type 2 management. Mounjaro from Eli

Before recently most GLP-1 agonists only gave a small amount of weight loss, and they've typically only been approved for type 2 management. Mounjaro from Eli Lilly though shows great promise with an average weight loss of 50 pounds per participant. It's been approved for type 2 management, but they've also submitted it to the FDA as a weight loss drug. On the first month on the lowest dose (no exercise), I lost 15 pounds. The good side is the injection is mostly pain-free, and easy to administer. You will feel a little prick, but it feels mostly like getting a burr stuck to your skin. The downside is it's $1000/month. Most insurance won't cover it yet. It also makes maybe more sense when insulin costs $5000/year or more. Right now there's a coupon which makes the co-pay $25 but that lasts for only 3 months. Side effects for me were decreased appetite (which is a good thing), low level nausea, and constipation. All of which were not deal breakers for me.