This is mostly from well-run population studies. The effect sizes are very large and robust, e.g. 40% for Tdap. Herpes treatment, from a small RCT in Asia. Hy

This is mostly from well-run population studies. The effect sizes are very large and robust, e.g. 40% for Tdap. Herpes treatment, from a small RCT in Asia. Hypothesis is that amyloids are a response to inflammation, and things that reduce inflammation (including blocking various infections) help. But nobody knows, really. Or is trying very hard to find out. It would be criminal negligence, except it is all perfectly legal, like most corruption in the US. Grant money for Alzheimer's research ($2B/y?) is controlled by people who have made a career of chasing ways to suppress amyloid production. They are not about to waste any on people they don't know wandering unlikely blind alleys when ways to suppress amyloid production (in these mice) are not fully explored. They divert some for tau tangles, and how much good has come of that?