There is a huge amount of genetic evidence that amyloid-beta or its precursor APP is involved and causal in Alzheimer's. That's not in question. But since ther

There is a huge amount of genetic evidence that amyloid-beta or its precursor APP is involved and causal in Alzheimer's. That's not in question. But since there's been so many trial failures trying to get rid of amyloid-beta, it has become clear that there's something missing to the story. I think talking of mafia or cabals is a bit exaggerated, but perhaps there has been a bit too much focus on the easy-to-see and study plaques and aggregates of amyloid-beta and to little on what happens before the plaques develop. (Something that is much harder)