6 ms·
Certainly about every paper nowadays is about stuff going on in a breed of mice engineered to produce lots of amyloid plaques. Hardly nobody knows or cares what
by ncmncm 4y ago
Certainly about every paper nowadays is about stuff going on in a breed of mice engineered to produce lots of amyloid plaques. Hardly nobody knows or cares what happens in actual patients.
The best methods we know of to protect real people against dementia are:
1. Get vaccinations. It doesn't seem to matter so much which ones. But Tdap and flu are seen to do the job.
2. Eat plenty of cheese.
3. Get treatment for herpes. I think valacyclovir is the mainstay.
4. Keep your gums healthy.
There is no rigorous information to indicate why these seem to make a difference. Precious few people are looking. Certainly the people in charge of grants for Alzheimer's research are not awarding them for any such effort.
When the whole house of amyloid cards finally collapses, what will amyloid specialists do with the rest of their careers? Maybe it would be smart to get a jump on that now...
- bilsbie 4y agoHow much of that is the healthy user bias though. Those are all things healthy people generally do.
- macrolime 4y agoHealthy people generally eats lots of cheese and valacyclovir?
- UncleOxidant 4y agoCheese? Where is that coming from?
- mmastrac 4y agoMost studies are done on mice... /s But seriously, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073537/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073537/ > Oleamide and dehydroergosterol identified from Camembert cheese induce microglia into the M2 anti-inflammatory phenotype, leading to neuroprotection. The mechanisms that regulate microglial activation and inflammation in Alzheimer’s disease are important targets for disease prevention. The regulation of microglia via daily lifestyle habits has been receiving increasing attention. The intake of neuroprotective and anti-inflammatory compounds including oleamide and dehydroergosterol in meals is safe and easy, so nutritional approaches are promising for the prevention of neurodegenerative disorders.
- AlbertCory 4y agoCamembert, the new SuperFood! Now there's some news I can use.
- ekianjo 4y agomice models are almost never applicable to humans... and I have a very hard time believing that simple foods play a major role in protection.
- canadiantim 4y agoWhere are you getting your information on the methods to protect against dementia? That seems like a very dubious list tbh
- ncmncm 4y agoThis is mostly from well-run population studies. The effect sizes are very large and robust, e.g. 40% for Tdap. Herpes treatment, from a small RCT in Asia. Hypothesis is that amyloids are a response to inflammation, and things that reduce inflammation (including blocking various infections) help. But nobody knows, really. Or is trying very hard to find out. It would be criminal negligence, except it is all perfectly legal, like most corruption in the US. Grant money for Alzheimer's research ($2B/y?) is controlled by people who have made a career of chasing ways to suppress amyloid production. They are not about to waste any on people they don't know wandering unlikely blind alleys when ways to suppress amyloid production (in these mice) are not fully explored. They divert some for tau tangles, and how much good has come of that?