4 ms·
There is so much that I hope gene hacking can do...
by godzillabrennus 4y ago
There is so much that I hope gene hacking can do...
- WalterSear 4y agoHuman clinical trials of a mRNA-based vaccine for some autoimmune diseases are currently underway, fwiw.
- mleonhard 4y agoPlease post a link.
- WalterSear 4y agohttps://clinicaltrials.gov/ct2/show/NCT04916431 https://clinicaltrials.gov/ct2/show/NCT04916431 https://www.biopharma-reporter.com/Article/2021/08/02/Moderna-takes-first-autoimmune-therapeutic-candidate-into-the-clinic https://www.biopharma-reporter.com/Article/2021/08/02/Modern... https://www.clinicaltrialsarena.com/news/moderna-trial-mrna-treatment/ https://www.clinicaltrialsarena.com/news/moderna-trial-mrna-... https://www.nature.com/articles/s41467-022-31130-9 https://www.nature.com/articles/s41467-022-31130-9
- echelon 4y agoUnfortunately the BCR and TCR spatial conformations that govern antigen binding affinity are a result of somatic recombination [1]. The genes edit themselves at runtime to fit their target better. It's stochastic hill climbing happening within us while we're alive. This would make it very difficult to target a specific gene to edit without having a wide blast radius. [1] https://en.wikipedia.org/wiki/V(D)J_recombination https://en.wikipedia.org/wiki/V(D)J_recombination
- beagle3 4y agoWe do have a blunt B-cell reset tool though. Rituximab has been in use for two decades now, and recently there are newer drugs based on the same idea that are even more human-compatible.