This really doesn’t work. BMR is a thing. Gut bacteria are a thing. How your body conserves energy is a thing. How your body tries to find efficiencies while d

This really doesn’t work. BMR is a thing. Gut bacteria are a thing. How your body conserves energy is a thing. How your body tries to find efficiencies while doing the same thing is a thing. Insulin is a thing. The only way the CICO model has any value is through it’s most trivial “physics based” interpretation at which point it’s not useful in any way. It’s like saying “Developing software is simple. It’s Code in, Executable out”. Its not wrong, but it’s also a completely pointless statement, which only serves to trivialize a complex issue and end discussion on it. You could write that comment on every software development related article on HN and dismiss the article as clickbait on that basis, which would obviously be ridiculous, even if your statement wouldn’t be wrong.