4 ms·
Memories of my first job, between high school and university, I worked as a technician in a pharmaceutical formulation lab. Our main project was a topical Diclo
by pacaro 4y ago
Memories of my first job, between high school and university, I worked as a technician in a pharmaceutical formulation lab. Our main project was a topical Diclofenac preparation. We worked on both creams and an aerosol (post foam) dispenser. Balancing solvents, waxes, surfactants, and propellant (also a solvent) to create a foam that dissolves at the right speed was an interesting challenge. I have no idea whether our product ever went to market as I moved on to university and other things.
IIRC we explicitly didn't use DMSO because of concerns with toxicity, and just accepted that the absorbance rate was astonishingly low, clinical trials suggested that it took 24-48 hours for the active ingredient to be detected in the blood.
My recollections are hazy, this was over 30 years ago