"After this self-attack, the resulting necrotic (but not apoptotic) neuronal breakdown products diffuse to adjacent neurons eliciting further release of Aβ, lea

"After this self-attack, the resulting necrotic (but not apoptotic) neuronal breakdown products diffuse to adjacent neurons eliciting further release of Aβ, leading to a chronic self-perpetuating autoimmune cycle. AD thus emerges as a brain-centric autoimmune disorder of innate immunity..." I'm not from the field and can't parse the language of this article, but I'm trying to figure out if they offer an explanation as to why all therapies which target Aβ have failed to result in an improvement, even when they succeed in reducing Aβ buildup? Maybe it's in there, and someone who knows the language of this field can summarize?