My advice is pick a framework you can get on with (and has mass market adoption, look at developer surveys) and stick with it. This likely means Vue/ react, you

My advice is pick a framework you can get on with (and has mass market adoption, look at developer surveys) and stick with it. This likely means Vue/ react, you don't need to worry about all these other ones for a little while if it's causing you stress. This space is maturing, react has remained a solid choice since I started working with it many years ago now (yes it has warts, but so do most alternatives). Regarding typescript, I think you'll need to get over your concerns if you want to remain in the web space. If you check any developer surveys it's only getting more popular. I doubht its going anywhere soon, and if it does the syntax will be likely be extremely similar, its a pretty natural way to add typing to JS.