Prion disease isn't just any misfolded protein; it's a misfold that: * Has a lower bond energy than the correct fold (so can't readily be fixed), and * Can ca

Prion disease isn't just any misfolded protein; it's a misfold that: * Has a lower bond energy than the correct fold (so can't readily be fixed), and * Can cause its correctly-folded version to also misfold. So far, as far as I'm aware, there have only ever been a handful of misfolds that fit this pattern.