4 ms·
> This can't be true, many bioscience people have commented assuring us that because Deep Fold doesn't literally spit out new proteins, its nothing new, and say
by COGlory 4y ago
> This can't be true, many bioscience people have commented assuring us that because Deep Fold doesn't literally spit out new proteins, its nothing new, and saying otherwise is misleading
From the article...
> But when they instructed microorganisms to make their creations in the labs, none of the 150 designs worked. “They didn’t fold at all: they were just gunk at the bottom of the test tube,” says Baker.
For the record, David Baker (and other groups) have been successfully designing new proteins just from their own understanding of protein folding, for years. So "Deep Fold" still has yet to catch up to our own limited human understanding.
- flobosg 4y agoThose 150 designs were probably early proofs of concept hallucinated using e.g. RoseTTAFold; Baker has been thinking about protein hallucination for a while already.
- samus 4y agoThis is for one of the approaches they used. The other approach described in TA had a "decent" (one in ten) success rate.