I would pay skepticism to entrepreneurial commentaries on AlphaFold (CEO of a company based on competing technology has hot take, who would have guessed?), but

I would pay skepticism to entrepreneurial commentaries on AlphaFold (CEO of a company based on competing technology has hot take, who would have guessed?), but I would mind the caveats and areas of improvement pointed out by domain experts i.e. Baker, AlQuraishi, etc. Keeping in mind that the latter usually spend more time praising AlphaFold than not -- and yes, they have more domain knowledge than pretty much anyone on HN: https://moalquraishi.wordpress.com/2021/07/25/the-alphafold2-method-paper-a-fount-of-good-ideas/ https://moalquraishi.wordpress.com/2021/07/25/the-alphafold2... It's almost entirely positive. There was a slice in time where I was effectively paid to find as many gaps in AlphaFold as I could, and, even then, I couldn't help but be impressed.