Stopping the metastatic surge cancer cells undergo, forming new tumor micro-environments (TME, angiogenesis), are probably the main areas research should focus

Stopping the metastatic surge cancer cells undergo, forming new tumor micro-environments (TME, angiogenesis), are probably the main areas research should focus on to radically boost long-term survival. We need to move cancer from a fatal condition to a chronic condition. We're sloooowly getting there with antibody drug conjugates like pembrolizumab (https://en.wikipedia.org/wiki/Pembrolizumab https://en.wikipedia.org/wiki/Pembrolizumab), but what truly causes metastatic spread (epithelial–mesenchymal transition) is still a mystery!