5 ms·

So what causes heart disease? Trans-fats, carbohydrates, sugar, lack of fiber? ... I guess it has been evident to me for a while that saturated fat doesn't caus

So what causes heart disease? Trans-fats, carbohydrates, sugar, lack of fiber? ... I guess it has been evident to me for a while that saturated fat doesn't cause heart disease, but it's not apparent what does.

wyager 4y ago
I would imagine that being sedentary and/or obese is a significant risk factor, although it is surprisingly difficult to quickly locate estimates of relative effect size. Official sites like the CDC's mostly reiterate the popular weak-effect nonsense about cholesterol etc. without any numeric scale comparisons.
Yiin 4y ago
Vegetable oils: https://www.youtube.com/watch?v=hzQAHITIUhg https://www.youtube.com/watch?v=hzQAHITIUhg
- dekken_ 4y ago
  yes, https://www.youtube.com/watch?v=rQmqVVmMB3k https://www.youtube.com/watch?v=rQmqVVmMB3k
resoluteteeth 4y ago
It seems like we really don't actually know. Sugar and trans-fats are the only things everyone can agree is bad, and it's not even totally clear whether sugar is actually that bad for people who aren't overweight and aren't sedentary (although most people are overweight and sedentary now anyway so it may not matter). (Even fiber, for example, might not be that important in itself so much as it is simply a proxy for vegetable consumption considering that fiber supplementation does nothing.)
- hackerlight 4y ago
  I think it's just added sugar and sugar found in processed food that is bad. Dark red fruits with high sugar content is good.
Blackthorn 4y ago
LDL. Which is awkward because it's an important molecule in the body, yet if it hits the arterial walls in such a way, the body has this crazy pathological response to it.
- boringg 4y ago
  I thought it went LDL repairs your cell walls so when your walls suffer from damage through inflammation LDL goes to patch it up.
- orangepurple 4y ago
  Oxidized LDL (oxLDL)
  - Blackthorn 4y ago
    Survey paper of interest (have not read, for future reference): https://www.frontiersin.org/articles/10.3389/fphar.2020.613780/full https://www.frontiersin.org/articles/10.3389/fphar.2020.6137...
chongli 4y ago
I think not enough has been said for the neurobiology of food. A lot of modern foods (high processed) have been engineered to maximize food rewards using a mixture of salt, fat, carbohydrates, and proteins / amino acids / MSG. These foods tend to be highly calorie dense and extremely rewarding / addictive while at the same time producing low satiety (so you don't feel full and want to keep eating). Doritos is the classic example of this.

wyager 4y ago

I would imagine that being sedentary and/or obese is a significant risk factor, although it is surprisingly difficult to quickly locate estimates of relative effect size. Official sites like the CDC's mostly reiterate the popular weak-effect nonsense about cholesterol etc. without any numeric scale comparisons.

Yiin 4y ago

Vegetable oils: https://www.youtube.com/watch?v=hzQAHITIUhg https://www.youtube.com/watch?v=hzQAHITIUhg

dekken_ 4y ago
yes, https://www.youtube.com/watch?v=rQmqVVmMB3k https://www.youtube.com/watch?v=rQmqVVmMB3k

resoluteteeth 4y ago

It seems like we really don't actually know. Sugar and trans-fats are the only things everyone can agree is bad, and it's not even totally clear whether sugar is actually that bad for people who aren't overweight and aren't sedentary (although most people are overweight and sedentary now anyway so it may not matter). (Even fiber, for example, might not be that important in itself so much as it is simply a proxy for vegetable consumption considering that fiber supplementation does nothing.)

hackerlight 4y ago
I think it's just added sugar and sugar found in processed food that is bad. Dark red fruits with high sugar content is good.

Blackthorn 4y ago

LDL. Which is awkward because it's an important molecule in the body, yet if it hits the arterial walls in such a way, the body has this crazy pathological response to it.

boringg 4y ago
I thought it went LDL repairs your cell walls so when your walls suffer from damage through inflammation LDL goes to patch it up.
orangepurple 4y ago
Oxidized LDL (oxLDL)
- Blackthorn 4y ago
  Survey paper of interest (have not read, for future reference): https://www.frontiersin.org/articles/10.3389/fphar.2020.613780/full https://www.frontiersin.org/articles/10.3389/fphar.2020.6137...

chongli 4y ago

I think not enough has been said for the neurobiology of food. A lot of modern foods (high processed) have been engineered to maximize food rewards using a mixture of salt, fat, carbohydrates, and proteins / amino acids / MSG. These foods tend to be highly calorie dense and extremely rewarding / addictive while at the same time producing low satiety (so you don't feel full and want to keep eating). Doritos is the classic example of this.